2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-140865
    2-(Azido-PEG3-amido)-1,3-bis(NHS ester) 2320560-36-7
    2-(Azido-PEG3-amido)-1,3-bis(NHS ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. 2-(Azido-PEG3-amido)-1,3-bis(NHS ester) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    2-(Azido-PEG3-amido)-1,3-bis(NHS ester)
  • HY-141295
    PEG3-bis-(ethyl phosphonate) 160625-24-1
    PEG3-bis-(ethyl phosphonate) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    PEG3-bis-(ethyl phosphonate)
  • HY-132093
    Azido-PEG5-S-methyl ethanethioate 1352221-64-7
    Azido-PEG5-S-methyl ethanethioate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG5-S-methyl ethanethioate is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG5-S-methyl ethanethioate
  • HY-163821
    HO-CONH-C3-PEG3-NH2 2136574-39-3
    HO-CONH-C3-PEG3-NH2 is a linker, that can be used for synthesis of PROTAC Degrader 22-SLF (HY-163807).
    HO-CONH-C3-PEG3-NH2
  • HY-130467
    DNP-NH-PEG2-C2-acid 1353011-89-8
    DNP-NH-PEG2-C2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    DNP-NH-PEG2-C2-acid
  • HY-130657
    m-PEG5-nitrile 81836-41-1
    m-PEG5-nitrile is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    m-PEG5-nitrile
  • HY-140621
    m-PEG3-0-benzaldehyde 153364-63-7
    m-PEG3-0-benzaldehyde is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG3-0-benzaldehyde
  • HY-159682
    3,8-Diazabicyclo[3.2.1]octane-4-pyrimidine-piperidine-cyclohexene-Bpin
    3,8-Diazabicyclo[3.2.1]octane-4-pyrimidine-piperidine-cyclohexene-Bpin is a PROTAC linker. 3,8-Diazabicyclo[3.2.1]octane-4-pyrimidine-piperidine-cyclohexene-Bpin can be used in the synthesis PROTAC SMARCA2/4-degrader-29 (HY-162743).
    3,8-Diazabicyclo[3.2.1]octane-4-pyrimidine-piperidine-cyclohexene-Bpin
  • HY-140065
    endo-BCN-PEG8-acid 2126805-02-3
    endo-BCN-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. endo-BCN-PEG8-acid is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    endo-BCN-PEG8-acid
  • HY-126883
    Tr-PEG4-OH 125274-16-0
    Tr-PEG4-OH is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    Tr-PEG4-OH
  • HY-126951
    Aminooxy-PEG2-alcohol 185022-12-2
    Aminooxy-PEG2-alcohol is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Aminooxy-PEG2-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Aminooxy-PEG2-alcohol
  • HY-140733
    Dioxoisoindolin-O-PEG-OMe (MW 2000)
    Dioxoisoindolin-O-PEG-OMe (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Dioxoisoindolin-O-PEG-OMe (MW 2000)
  • HY-140635
    Ald-CH2-PEG8-azide 2353410-13-4
    Ald-CH2-PEG8-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Ald-CH2-PEG8-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Ald-CH2-PEG8-azide
  • HY-138468
    Boc-PEG25-benzyl
    Boc-PEG25-benzyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-PEG25-benzyl
  • HY-140983
    m-PEG12-Mal 2853560-28-6
    m-PEG12-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG12-Mal
  • HY-130152
    Ms-PEG7-MS 109789-41-5
    Ms-PEG7-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Ms-PEG7-MS
  • HY-133318
    Azido-PEG16-acid 3080184-80-8
    Azido-PEG16-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG16-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG16-acid
  • HY-140081
    Boc-gly-PEG3-endo-BCN 2110444-63-6
    Boc-gly-PEG3-endo-BCN is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Boc-gly-PEG3-endo-BCN is also a cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-gly-PEG3-endo-BCN is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    Boc-gly-PEG3-endo-BCN
  • HY-156389
    (R)-TCO4-PEG2-NH2
    (R)-TCO4-PEG2-NH2 is a PROTAC linker and belongs to the PEG class. (R)-TCO4-PEG2-NH2 contains a TCO group that specifically "clicks" with the tetrazine group.
    (R)-TCO4-PEG2-NH2
  • HY-140239
    Amino-PEG4-benzyl ester 1351397-21-1
    Amino-PEG4-benzyl ester is a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG4-benzyl ester
PROTAC Linkers Isoform Comparison

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